Event Title

Examination of Prefrontal Cortex Microglia Morphology in Males and Females in a Mouse Model of Acute Ethanol Intoxication

Presenter Information

Jordan Zezza, Susquehanna University

Start Date

25-4-2017 2:20 PM

End Date

25-4-2017 2:40 PM

Description

Ethanol use has been shown to have adverse effects on the brain, sometimes leading to psychiatric disorders likely due to changes in stress-related regions such as the ventromedial prefrontal cortex (vmPFC). Interestingly, evidence suggests that females may be more susceptible to some of these disorders than men. Often, activation of microglia, the innate immune cells of the central nervous system, is associated with psychiatric disease. In the present study, we investigated if changes occurred in microglial activity in the vmPFC in an acute model of ethanol intoxication, and further, if those changes were more substantial in females compared to males. To examine relative changes in microglial activity, we used morphological parameters such as soma area and branching complexity of the cell’s processes. Understanding the role of neuroimmune dysfunction in the development of psychiatric disorders may help pave the way to better public health and treatments in the future.

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Apr 25th, 2:20 PM Apr 25th, 2:40 PM

Examination of Prefrontal Cortex Microglia Morphology in Males and Females in a Mouse Model of Acute Ethanol Intoxication

Ethanol use has been shown to have adverse effects on the brain, sometimes leading to psychiatric disorders likely due to changes in stress-related regions such as the ventromedial prefrontal cortex (vmPFC). Interestingly, evidence suggests that females may be more susceptible to some of these disorders than men. Often, activation of microglia, the innate immune cells of the central nervous system, is associated with psychiatric disease. In the present study, we investigated if changes occurred in microglial activity in the vmPFC in an acute model of ethanol intoxication, and further, if those changes were more substantial in females compared to males. To examine relative changes in microglial activity, we used morphological parameters such as soma area and branching complexity of the cell’s processes. Understanding the role of neuroimmune dysfunction in the development of psychiatric disorders may help pave the way to better public health and treatments in the future.