Event Title

Synthesis of Thujone Derivatives as Potential Antibacterial Agents

Presenter Information

Emily Castner

Faculty Advisor

Dr. Geneive Henry

Start Date

24-4-2018 5:00 PM

End Date

24-4-2018 6:00 PM

Description

Alpha-thujone and beta-thujone are the major components of the essentials oil of Thuja occidentalis (white cedar). In addition to anticancer, insecticidal and nervous system effects, the thujones have shown antibacterial activity against a range of gram-positive and gram-negative bacterial strains, with MIC values ranging from 0.09-0.95 mg/mL. In the current study, twelve thujol esters were synthesized using a mixture of alpha and beta thujones (7:1 ratio) as starting material. The thujone mixture was reduced with sodium borohydride, followed by esterification of the resulting diastereomeric alcohols. The esters were evaluated for growth inhibitory effects against clinically isolated Staphylococcus aureus strains.

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Apr 24th, 5:00 PM Apr 24th, 6:00 PM

Synthesis of Thujone Derivatives as Potential Antibacterial Agents

Alpha-thujone and beta-thujone are the major components of the essentials oil of Thuja occidentalis (white cedar). In addition to anticancer, insecticidal and nervous system effects, the thujones have shown antibacterial activity against a range of gram-positive and gram-negative bacterial strains, with MIC values ranging from 0.09-0.95 mg/mL. In the current study, twelve thujol esters were synthesized using a mixture of alpha and beta thujones (7:1 ratio) as starting material. The thujone mixture was reduced with sodium borohydride, followed by esterification of the resulting diastereomeric alcohols. The esters were evaluated for growth inhibitory effects against clinically isolated Staphylococcus aureus strains.