Event Title

Forget the Stress: Retrograde Amnesia for Restraint Enhances Extinction Learning

Presenter Information

Leigh Ann Greenwald
Una Heinzelring

Faculty Advisor

Dr. James Briggs

Start Date

24-4-2018 4:00 PM

End Date

24-4-2018 5:00 PM

Description

Stress has been found to influence learning in different ways. In particular, previous research has shown that stress enhances original learning but disrupts extinction learning. The aim of our experiments was to replicate earlier findings that acute stress would disrupt extinction learning using a passive avoidance paradigm with rats. The second aim was to determine whether cycloheximide (a protein synthesis inhibitor commonly used as an amnestic agent) given immediately following the restraint stressor would block the stress effects on extinction learning. Results showed that we were able to replicate the effects of acute stress blocking extinction learning in rats; in addition, our results demonstrated that the stress event is susceptible to retrograde amnesia.

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Apr 24th, 4:00 PM Apr 24th, 5:00 PM

Forget the Stress: Retrograde Amnesia for Restraint Enhances Extinction Learning

Stress has been found to influence learning in different ways. In particular, previous research has shown that stress enhances original learning but disrupts extinction learning. The aim of our experiments was to replicate earlier findings that acute stress would disrupt extinction learning using a passive avoidance paradigm with rats. The second aim was to determine whether cycloheximide (a protein synthesis inhibitor commonly used as an amnestic agent) given immediately following the restraint stressor would block the stress effects on extinction learning. Results showed that we were able to replicate the effects of acute stress blocking extinction learning in rats; in addition, our results demonstrated that the stress event is susceptible to retrograde amnesia.