Event Title

Retrograde Amnesia for a UCS Preexposure Memory

Presenter Information

Alexa Iannitelli

Faculty Advisor

Dr. James Briggs

Start Date

24-4-2018 5:00 PM

End Date

24-4-2018 6:00 PM

Description

The UCS preexposure effect is a phenomenon in which exposure to an unconditioned stimulus (UCS) prior to its pairing with a conditioned stimulus (CS) retards later learning, while also producing a competing memory. The current studies aim to investigate whether preexposure to a UCS is susceptible to amnesia. The first experiment demonstrated the UCS preexposure effect using a tone-shock fear conditioning paradigm. After validating the UCS preexposure effect in Experiment 1, the second experiment investigated whether administration of an amnestic agent, cycloheximide, would prevent the inhibitory effect of UCS preexposure. Results showed animals in the saline control group demonstrated less freezing behaviors than the experimental animals when tested. These findings provide evidence that cycloheximide (a protein synthesis inhibitor) caused amnesia for preexposure, and alleviating the competing memory formed by UCS preexposure.

This document is currently not available here.

Share

COinS
 
Apr 24th, 5:00 PM Apr 24th, 6:00 PM

Retrograde Amnesia for a UCS Preexposure Memory

The UCS preexposure effect is a phenomenon in which exposure to an unconditioned stimulus (UCS) prior to its pairing with a conditioned stimulus (CS) retards later learning, while also producing a competing memory. The current studies aim to investigate whether preexposure to a UCS is susceptible to amnesia. The first experiment demonstrated the UCS preexposure effect using a tone-shock fear conditioning paradigm. After validating the UCS preexposure effect in Experiment 1, the second experiment investigated whether administration of an amnestic agent, cycloheximide, would prevent the inhibitory effect of UCS preexposure. Results showed animals in the saline control group demonstrated less freezing behaviors than the experimental animals when tested. These findings provide evidence that cycloheximide (a protein synthesis inhibitor) caused amnesia for preexposure, and alleviating the competing memory formed by UCS preexposure.