Event Title

Singlet oxygen generation by gold nanoparticles: Detection and applications

Faculty Advisor

Dr. Swarna Basu

Start Date

23-4-2019 4:00 PM

End Date

23-4-2019 5:00 PM

Description

Singlet oxygen can be generated by photoilluminenscence of Au nanoparticles. The singlet oxygen generated can be monitored indirectly by the absorbance of 9,10-anthracenediyl-bis(methylene) dimalonic acid (ABDA) in water. ABDA reacts irreversibly with singlet oxygen causing a decrease in absorbance at 380nm. Another chemical that can be used to detect singlet oxygen is 1,3-diphenylisobenzofuran (DPBF). DPBF will photobleach at 412nm without nanoparticles in solution, however in the presence of nanoparticles, the photobleaching is more prominent. Ascorbic acid can be used to reverse this reaction by preventing the reaction between singlet oxygen and either ABDA or DPBF. Aggregated nanoparticles have been shown to enhance singlet oxygen generation using KBr or cysteine. Nanoparticles of different shapes and sizes may increase the generation of singlet oxygen, which can be monitored using indirect methods. Singlet oxygen, generated by the excitation of Au nanoparticles, can be used for a variety of medical applications.

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Apr 23rd, 4:00 PM Apr 23rd, 5:00 PM

Singlet oxygen generation by gold nanoparticles: Detection and applications

Singlet oxygen can be generated by photoilluminenscence of Au nanoparticles. The singlet oxygen generated can be monitored indirectly by the absorbance of 9,10-anthracenediyl-bis(methylene) dimalonic acid (ABDA) in water. ABDA reacts irreversibly with singlet oxygen causing a decrease in absorbance at 380nm. Another chemical that can be used to detect singlet oxygen is 1,3-diphenylisobenzofuran (DPBF). DPBF will photobleach at 412nm without nanoparticles in solution, however in the presence of nanoparticles, the photobleaching is more prominent. Ascorbic acid can be used to reverse this reaction by preventing the reaction between singlet oxygen and either ABDA or DPBF. Aggregated nanoparticles have been shown to enhance singlet oxygen generation using KBr or cysteine. Nanoparticles of different shapes and sizes may increase the generation of singlet oxygen, which can be monitored using indirect methods. Singlet oxygen, generated by the excitation of Au nanoparticles, can be used for a variety of medical applications.