Faculty Advisor

Dr. William Dougherty

Start Date

27-4-2021 12:00 AM

End Date

27-4-2021 12:00 AM

Description

Several ketones and aldehydes were hydrogenated with Frustrated Lewis pair (FLP) conditions using microwave irradiation. Several of these products were characterized by spectroscopic techniques. Cyclopentyl methyl ether (CPME) was found to be the most efficient solvent under microwave conditions. Stereoselectivity of hydride addition was varied with cyclohexanone derivatives and depended on the proximity of large groups to the electrophilic center. The reaction rates of benzaldehyde and acetophenone derivatives were calculated to compare effects of electron withdrawing groups. The use of the microwave successfully reduced reaction times from several hours to just a few minutes in the most extreme cases.

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Apr 27th, 12:00 AM Apr 27th, 12:00 AM

Investigation of Microwave Assisted Hydrogenations Using Frustrated Lewis Pairs​

Several ketones and aldehydes were hydrogenated with Frustrated Lewis pair (FLP) conditions using microwave irradiation. Several of these products were characterized by spectroscopic techniques. Cyclopentyl methyl ether (CPME) was found to be the most efficient solvent under microwave conditions. Stereoselectivity of hydride addition was varied with cyclohexanone derivatives and depended on the proximity of large groups to the electrophilic center. The reaction rates of benzaldehyde and acetophenone derivatives were calculated to compare effects of electron withdrawing groups. The use of the microwave successfully reduced reaction times from several hours to just a few minutes in the most extreme cases.

 

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